Distribution of Enprofylline and Theophylline Between Plasma and Cerebrospinal Fluid
作者:
Lars Laursen,
Olof Borgå,
Lisbeth Krohn,
Bent Weeke,
期刊:
Therapeutic Drug Monitoring
(OVID Available online 1989)
卷期:
Volume 11,
issue 2
页码: 162-164
ISSN:0163-4356
年代: 1989
出版商: OVID
关键词: Enprofylline;Theophylline;Plasma;Cerebrospinal fluid.
数据来源: OVID
摘要:
Six patients undergoing diagnostic lumbar myelography were studied with respect to plasma and cerebrospinal fluid (CSF) concentrations of two xanthine drugs—enprofylline and theophylline. Three patients received enprofylline and three patients received theophylline, 200 mg t.i.d., and plasma and CSF were sampled on the morning of the third day of treatment. CSF plasma ratios averaged 0.095 with enprofylline (range of 0.094–0.097) and 0.36 with theophylline (range of 0.35–0.37). The different ratios of the two drugs contrast to their similar plasma protein binding, about 50%. Different lipophilicity or differences with regard to transport out of the CSF may explain the discrepancy.
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