Diagnostic Utility of Microphthalmia Transcription Factor in Malignant Melanoma and Other Tumors
作者:
Karen Chang,
Andrew Folpe,
期刊:
Advances in Anatomic Pathology
(OVID Available online 2001)
卷期:
Volume 8,
issue 5
页码: 273-275
ISSN:1072-4109
年代: 2001
出版商: OVID
关键词: Microphthalmia transcription factor;Malignant melanoma;Perivascular epithelioid cell;Clear cell sarcoma;Diagnosis;Monoclonal antibodies;Immunohistochemistry
数据来源: OVID
摘要:
The diagnosis of malignant melanoma is sometimes challenging. Immunohistochemistry for specific markers of melanocytic differentiation such as HMB-45 and Melan-A can be very valuable in proving melanocytic differentiation in poorly differentiated or spindled forms of melanoma. Microphthalmia-associated transcription factor (MiTF) is the most recently described and the only nuclear melanocytic marker. This article reviews the biology of MiTF and those published studies that have addressed its diagnostic sensitivity and specificity. MiTF may be very valuable for the diagnosis of melanoma, including desmoplastic variants; melanocytic soft tissue tumors, such as clear cell sarcoma; and the unusual group of tumors that show combined melanocytic and myoid differentiation, the perivascular epithelioid cell family of tumors (PEComas).
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