Changes in Peripheral Blood Cells in Mice After Injection with Benzo(A)Pyrene During Pregnancy
作者:
UrsoPaul,
RyanMark C.,
BennettJudith S.,
期刊:
Immunopharmacology and Immunotoxicology
(Taylor Available online 1988)
卷期:
Volume 10,
issue 2
页码: 179-193
ISSN:0892-3973
年代: 1988
DOI:10.3109/08923978809014332
出版商: Taylor&Francis
数据来源: Taylor
摘要:
AbstractPregnant C3H/Anfcum mice were injected ip with 150 ug benzo-(a)pyrene (BP)/g body weight at the second trimester (12 days). Quantitative and differential changes were assayed in the peripheral blood leukocytes and erythrocytes at various times before and after mating and treatment. Within 5 days after injection, a 2- to 4-fold reduction in leukocytes was observed when compared to controls [corn oil (vehicle for BP)-injected pregnant females] which persisted into the 10th postpartum day. The erythrocytes were also significantly reduced but not to the same degree (1.2- to 1.5-fold). Depression in white blood cells is attributed to lymphocyte depletion since the granulocytes were virtually unchanged and the lymphocyte to granulocyte ratio, ordinarily>2 was 1 or
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