Absolute Identification of Hb D-Los Angeles (β121 GLU→GLN)
作者:
BrennanS. O.,
期刊:
Hemoglobin
(Taylor Available online 1977)
卷期:
Volume 1,
issue 6
页码: 571-576
ISSN:0363-0269
年代: 1977
DOI:10.3109/03630267709003421
出版商: Taylor&Francis
数据来源: Taylor
摘要:
This paper describes a method which permits the absolute identification of Hb D-Los Angeles Bithout the need for N-terminal or amino acid analysis on peptideβT-13. The procedure involves the formation of the 5-oxo-2-pyrrolidinecarboxylyl derivative of the N-terminal glutamine residue ofβDT-13. This method, together with the use of cadmium ncetate/ninhydrin staining, allows the identification of Hb D-Los Angeles, and other possible mutntions of p121, by peptide mapping.
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