Spectrophotometric Determination Of Rifampin in the Presence of its Degradation Products in Pharmaceutical Preparations
作者:
M.I. Walash,
F. Belal,
M.E. Metwally,
M.Mt. Hefnawy,
期刊:
Analytical Letters
(Taylor Available online 1993)
卷期:
Volume 26,
issue 9
页码: 1905-1917
ISSN:0003-2719
年代: 1993
DOI:10.1080/00032719308017439
出版商: Taylor & Francis Group
关键词: Rifampin;Pharmaceutical Preparations;Spectrophotometric Procedure
数据来源: Taylor
摘要:
The determination of rifampin in the presence of its main degradation products, 3-formyl rifampin and rifampin quinone using two spectrophotometric methods is described. Both Glenn's method and first derivative spectrophotometry were successfully adopted. No preliminary separation steps were required in either cases. Both methods gave accurate and reproducible results for the determination of the drug in dosage forms. The percentage recoveries ranged from 99.33% ±0.63 to 100.2% ± 0.44. The proposed methods are more simple, rapid than other existing methods and can be readily adopted in control laboratory.
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