Comparison of Platelet Concentrates Stored in Plasma and in Three Plasmafree Media
作者:
TurnerV. S.,
HarrisA.,
DawR. A.,
期刊:
Platelets
(Taylor Available online 1990)
卷期:
Volume 1,
issue 3
页码: 155-161
ISSN:0953-7104
年代: 1990
DOI:10.3109/09537109009005481
出版商: Taylor&Francis
数据来源: Taylor
摘要:
Platelet concentrates (PC) were stored for 7 days at 22°C in either CPDA-1 plasma (control) or one of three plasma-free media, namely a Tyrodes solution (BTST) fortified with citrate and with additional phosphate for buffering effect; Plasma-Lyte A solution (PCD) fortified with dextrose and citrate; and Ringers/CPD-50 (10:1) solution (RCPD) buffered with phosphate, all with a pH of 7.4. Parameters monitored included platelet count, pH, hypotonic shock response, aggregation response to single and paired agonists, and release by platelets of endogenous LDH, ATP and 5HT. BTST was shown to be a satisfactory plasma substitute over the entire storage period. PCD gave similar results over 4 days, although the decrease in pH was more marked. In all test systems RCPD was shown to be a poor plasma substitute.
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