Correlation between Histochemically Assessed Hormonal Receptor Content and Clinical Course in Breast Cancer
作者:
Ornella Gottardi,
Claudia Baiocchi,
Massimo Ferrari,
Luigina Franchi,
Marcello Gambacorta,
Giuseppe Landonio,
Nina Pinna,
Enrico Ghislandi,
期刊:
Oncology
(Karger Available online 1991)
卷期:
Volume 48,
issue 3
页码: 221-225
ISSN:0030-2414
年代: 1991
DOI:10.1159/000226931
出版商: S. Karger AG
关键词: Breast cancer;Hormonal receptors;Histochemical assessment;Prognostic value
数据来源: Karger
摘要:
Lee’s histochemical method was used to assess hormonal receptors in 1,005 patients with breast cancer. Patients were from 8 oncological departments in northern Italy. The group was subdivided into four subgroups in relation to menopausal status and presence or absence of axillary node metastasis. Overall survival (OS) and disease-free survival (DFS) were analysed in all subgroups in relation to receptorial status. We observed: (1) when hormonal receptors are present, OS and DFS are longer in all subgroups; (2) the presence of hormonal receptors influences favourably both DFS and OS, but it seems to play a more important role for DFS; (3) the positive receptorial status is a better prognostic factor in groups without axillary node metastasis, especially in premenopausal patients. We conclude that the histochemical assessment of hormonal receptors is a valid method for the prognostic evaluation of patients with breast cance
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