Inhibition of normal human granulopoiesis by neuroblastoma cells
作者:
Raymond,
Hutchinson Robert,
McAlack Audrey,
Evans Loretta,
期刊:
American Journal of Pediatric Hematology/Oncology
(OVID Available online 1983)
卷期:
Volume 5,
issue 2
页码: 133-138
ISSN:0192-8562
年代: 1983
出版商: OVID
数据来源: OVID
摘要:
ABSTRACTIn vitroinhibition of marrow granulopoiesis was produced by a well-characterized human neuroblastoma cell line (CHP 134). A standard double layer, semi-solid agar system was employed in the experiments. The inhibition was present whether the neuroblastoma cells were mixed with the marrow cells or whether they were separated in a contiguous agar layer. Irradiation of the neuroblastoma cells lessened the inhibitory effect but did not eradicate it. Medium conditioned by the neuroblastoma cells had a mild, but not statistically significant, suppressive effect upon granulopoiesis. Additional studies to define the precise mechanism of suppression are under-way.
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