An Immunoelectron-Microscopical Observation of Mouse Juxtaglomerular Cells in the Case of Experimental Hydronrophrosis
作者:
Y. Kon,
Y. Hashimoto,
K. Murakami,
M. Sugimura,
期刊:
Cells Tissues Organs
(Karger Available online 1992)
卷期:
Volume 144,
issue 4
页码: 354-362
ISSN:1422-6405
年代: 1992
DOI:10.1159/000147330
出版商: S. Karger AG
关键词: Hydronephrosis;Immunoelectron microscopy;Juxtaglomerular cells;Mouse;Renin
数据来源: Karger
摘要:
Changes in juxtaglomerular (JG; renin-containing) cells in experimental hydronephrosis 1 month after ureteral ligation were investigated with immunoelectron-microscopical techniques. Two types of granules, electron dense (D) and lucent (L), were observed. D type granules were labeled more intensely with gold particles than those of L type. Granules intermediate between D and L types and exocytosis of D types were observed. In the cells containing D types exclusively, gold particles were restricted to the granules, whereas in the cells containing both D and L type granules, the particles were scattered throughout the cytoplasmic cytosol. The authors discuss the mechanisms of renin release in JG cells.
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