Depot preparations of disulfiram: experimental and clinical results
作者:
J. Johnsen,
J. Mørland,
期刊:
Acta Psychiatrica Scandinavica
(WILEY Available online 1992)
卷期:
Volume 86,
issue S369
页码: 27-30
ISSN:0001-690X
年代: 1992
DOI:10.1111/j.1600-0447.1992.tb03311.x
出版商: Blackwell Publishing Ltd
关键词: Disulfiram;implants;sustained‐release preparations;review
数据来源: WILEY
摘要:
AbstractPatient compliance with disulfiram is a troublesome clinical problem. Several strategies have been proposed as a solution to the problem, including subcutaneous implantation of disulfiram. However, well controlled studies of alcoholics and healthy volunteers have failed to discover a pharmacological effect of implanted disulfiram. A major reason for this failure appears to be poor absorption from an inadequate dose. Assessment of new sustained release formulation of depot disulfiram has been found to provoke a mild disulfiram‐ethanol reaction (DER). Only a more severe DER would be expected to deter further drinking. If problems with absorption and appropriate dosing of disulfiram can be resolved or a depot preparation of the active metabolite of disulfiram can be prepared, implants might find continued clinical us
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