Semiautomated Enzyme Immunoassay of Thyrotropin as a Mass Screening Test for Neonatal Hypothyroidism
作者:
KIYOSHI MIYAI,
TSUNEO TSURUHARA,
SATOSHI KUSUDA,
KAICHIRO ISHIBASHI,
MINORU KAWASHIMA,
HITOSHI MIZUTA,
OSAMU NOSE,
HYAKUJI YABUUCHI,
TOSHIAKI OURA,
期刊:
Pediatric Research
(OVID Available online 1984)
卷期:
Volume 18,
issue 12
页码: 1289-1292
ISSN:0031-3998
年代: 1984
出版商: OVID
数据来源: OVID
摘要:
A sensitive, simple, and rapid semiautomated sandwich enzyme immunoassay (EIA) was developed for measuring thyrotropin in dried blood samples on filter paper for use in screening for neonatal hypothyroidism. Good correlation was found between values for thyrotropin determined by this method and those determined by radioimmunoassay (RIA) (r=0.94). In pilot tests on 17,160 newborn infants in the general population, five cases of primary hypothyroidism were detected by both EIA and RIA. The recall rate was slightly higher in EIA than in RIA.
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