Disease management is a systematic population-based approach to identifying those at risk, intervening using information from the growing field of evidencebased medicine, and measuring patient outcomes once an intervention is in effect. Operationally, this is a challenging series of tasks, and a vulnerability for this field. Important aspects include the development of clear clinical guidelines, agreement on the part of providers and patients to participate, a sophisticated information architecture, well-designed and tested interventions and a logical measurement plan for the collection of outcomes. While there is a clear need for evidence of its benefit, the field is expanding rapidly and incorporating many other disciplines and aspects of healthcare delivery as well.