Hypoadiponectinemia Is an Independent Risk Factor for Hypertension
作者:
Yoshio Iwashima,
Tomohiro Katsuya,
Kazuhiko Ishikawa,
Noriyuki Ouchi,
Mitsuru Ohishi,
Ken Sugimoto,
Yuxiao Fu,
Masaharu Motone,
Kouichi Yamamoto,
Akiko Matsuo,
Koji Ohashi,
Shinji Kihara,
Tohru Funahashi,
Hiromi Rakugi,
Yuji Matsuzawa,
Toshio Ogihara,
期刊:
Hypertension: Journal of The American Heart Association
(OVID Available online 2004)
卷期:
Volume 43,
issue 6
页码: 1318-1323
ISSN:0194-911X
年代: 2004
出版商: OVID
关键词: blood pressure;genetics;hypertension, genetic;men;mutation
数据来源: OVID
摘要:
Adiponectin is one of the key molecules in the metabolic syndrome, and its concentration is decreased in obesity, type-2 diabetes, and coronary artery disease. Genetic investigation has revealed that 2 polymorphisms (I164T and G276T) are related to adiponectin concentration and diabetes. To examine whether adiponectin affects hypertension genetically or biologically, we performed a case-control study. A total of 446 diagnosed cases of hypertension (HT) in men and 312 normotensive (NT) men were enrolled in this study. Plasma adiponectin concentration was measured using an enzyme-linked immunosorbent assay system. Single nucleotide polymorphisms were determined by TaqMan polymerase chain reaction method. After adjustment for confounding factors, adiponectin concentration was significantly lower in HT (HT: 5.2±0.2 μg/mL; NT: 6.1±0.2 μg/mL;P<0.001). Furthermore, multiple regression analysis indicated that hypoadiponectinemia was an independent risk factor for hypertension (P<0.001). Blood pressure was inversely associated with adiponectin concentration in normotensives regardless of insulin resistance. In subjects carrying the TC genotype of the I164T polymorphism, adiponectin concentration was significantly lower (TC: 2.6±0.9 μg/mL; TT: 5.5±0.1 μg/mL;P<0.01), and most of them had hypertension. In contrast, the G276T polymorphism was not associated with adiponectin concentration or hypertension. In conclusion, hypoadiponectinemia is a marker for predisposition to hypertension in men.
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