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Simultaneous Spectrophotometric Determination of Hydrochlorothiazide and Pharmaceutical Preparations

 

作者: E. Martín,   O. Hernández,   F. Jiménez,   J.J. Arias,  

 

期刊: Analytical Letters  （Taylor Available online 1995）
卷期: Volume 28, issue 8  

页码: 1449-1464

 

ISSN:0003-2719

 

年代: 1995

 

DOI:10.1080/00032719508006406

 

出版商: Taylor & Francis Group

 

关键词: Spectrophotometry;amiloride;hydrochlorothiazide;pharmaceuticals;simultaneous determination

 

数据来源: Taylor

 

摘要:

We developed three methods for the simultaneous determination of amiloride (AMI) and hydrochlorothiazide (HCT): zero-crossing, derivative quotient spectra with normalized divisor and multiple linear regression (MULTIC) methods. The two first methods use the derivative spectrophotometry, and the last one uses the absorbance measurement. The three methods were used to determine both compounds in synthetic mixtures and pharmaceutical preparations with errors less than 5% and 15%, respectively.

 

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