Myelodysplastic Syndrome with Multilineage Blast Transformation: Special Stains for Optimal Cytodiagnosis
作者:
ChouWu,
FungChyurng,
ShowFang,
TsaiWoei,
期刊:
Journal of Histotechnology
(Taylor Available online 1990)
卷期:
Volume 13,
issue 1
页码: 67-70
ISSN:0147-8885
年代: 1990
DOI:10.1179/his.1990.13.1.67
出版商: Taylor&Francis
关键词: cytochemistry;differential diagnosis;immunocytochemistry;myelodysplastic syndrome;multilineage leukemia
数据来源: Taylor
摘要:
AbstractTransformation of myelodysplastic syndrome to hematologic malignancies is not uncommon, but involvement of three committed progenitor cell lines at one time is seldom seen. We present a case of myelodysplastic syndrome with blast transformation, neoplastic cells that were difficult to classify morphologically, and basophilia found in marrow and peripheral blood. Differential diagnosis included myeloblastic leukemia, erythroblastic leukemia, megakaryoblastic leukemia, basophiloblastic leukemia, and systemic mast cell disease (SMCD). By using a battery of cytochemical techniques niques and irnrnuno~tochemicalm ethods, we were able to demonstrate the presence of myeloblasts, erythroblasts, and megakaryoblasts, thus excluding the possibility of SMCD and basophiloblastic leukemia. (The J Histotechnol13:67, 1990)
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