Effect of Heparin on Lipoprotein Profile During Parenteral Fat Infusions
作者:
A. Benderly,
E. Rosenthal,
J. Levi,
G. Brook,
期刊:
Journal of Parenteral and Enteral Nutrition
(WILEY Available online 1983)
卷期:
Volume 7,
issue 1
页码: 37-39
ISSN:0148-6071
年代: 1983
DOI:10.1177/014860718300700137
出版商: SAGE Publications
数据来源: WILEY
摘要:
Long‐term administration of Intralipid to infants raises the potential risk of cumulative hyperlipemia. The elimination of lipoproteins from the blood during 3 hours of Intralipid infusion (0.33 grams per kilogram per hour) was investigated in five term infants during two infusion periods without and with heparin. A single intravenous injection of heparin (100 micron per kilogram) preceded the period of Intralipid infusion. During the nonheparin periods levels of triglycerides (L‐particles) rose progressively to 1320±133 milligrams per 100 milliliters plasma, whereas during the heparin periods levels rose more moderately and peaked at 636±107 milligrams per 100 milliliter plasma (p<0.001–0.05). The study suggests that the heparin effect is still apparent for a period of 6 hours and repeated bolus injections may keep triglyceride levels at approximately normal concentrations during constant Intralipid infusion (0.166 grams per kilograms per hour).
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