首页   按字顺浏览 期刊浏览 卷期浏览 Left Ventricular Internal Resistance and Unloaded Ejection Flow Assessed From Pressure&...
Left Ventricular Internal Resistance and Unloaded Ejection Flow Assessed From Pressure‐Flow RelationsA Flow‐Clamp Study on Isolated Rabbit Hearts

 

作者: Simon Vaartjes,   Herman Boom,  

 

期刊: Circulation Research  (OVID Available online 1987)
卷期: Volume 60, issue 5  

页码: 727-737

 

ISSN:0009-7330

 

年代: 1987

 

出版商: OVID

 

关键词: ventricular mechanics;rabbit isolated heart;flow-clamp technique;pressure-flow relations;ventricular internal resistance;3-component mechanical model;Qmax

 

数据来源: OVID

 

摘要:

Left ventricular pressure-flow relations were studied, using excised working rabbit hearts and imposing constant flow ejections (flow-clamps) to separate the effects of flow on pressure from those of time, flow duration, starting volume, ejected volume, and volume at specified time. Pressure-flow data at given volume and time were independent of flow duration, starting volume, and ejected volume for flow-clamp durations exceeding 30 msec. Flow history independent of pressure-flow relations was linear for flow values larger than ± 5 ml/sec. The time-varying elastance model, E(t), of the ventricle was extended with a resistive component. Transient effects of flow can be explained by including a second elastance. The resulting verified 3-component model is consistent with recent reported experimental findings. The properties of internal resistance correspond to a constant unloaded ejection flow Qmax which was tested by extrapolating the linear pressure-flow relations to zero pressure. Qmax reached a plateau value of approximately 25 ml/sec within 50 msec after the start of contration. In relaxation, Qmax is only slightly smaller. Qmax did not depend on volume; therefore, the following equation was adequate for the relation between pressure, p(t); volume, V(t); and flow Q(t), during the flow-clamped ejections from 30 minutes after the start of the flow: (t) = E(t)±(V(t) - Vd)±(l - QW/Qmax)

 

点击下载:  PDF (1783KB)



返 回