AbstractA series of 5,6‐disubstituted 3‐alkoxypyrazine‐2‐carbonitriles (2a‐i) were prepared from 5,6‐disubstituted pyrazine‐2,3‐dicarbonitriles (1a‐d) by direct substitution with alcohols. Treatment of1with amines gave either pyrrolopyrazines (3a,b) or substitution products (4,5). In a low temperature range,1afforded imidates and related compounds (6–11). The preference among these reactions depended on the 5,6‐substituents and on th