首页   按字顺浏览 期刊浏览 卷期浏览 Differences in clinical course in zidovudine‐treated asymptomatic HIV‐inf...
Differences in clinical course in zidovudine‐treated asymptomatic HIV‐infected men associated with T‐cell function at intake

 

作者: Rob Gruters,   Fokke Terpstra,   Joep Lange,   Marijke Roos,   Thea Harkema,   Jan Mulder,   Frank Wolf,   Peter Schellekens,   Frank Miedema,  

 

期刊: AIDS  (OVID Available online 1991)
卷期: Volume 5, issue 1  

页码: 43-48

 

ISSN:0269-9370

 

年代: 1991

 

出版商: OVID

 

关键词: Immunology;zidovudine;AIDS;asymptomatic;therapy;CD3

 

数据来源: OVID

 

摘要:

Declining CD4+ T-cell numbers and anti-CD3-induced T-cell responsiveness are prognostic markers for progression of HIV infection. We investigated the effect of long-term (2-year) zidovudine treatment on these immunological markers in a group of nine asymptomatic p24-antigenaemic men, five of whom progressed to AIDS. A group of 10 untreated HIV-infected men, five of whom progressed to AIDS, was studied as a control. At intake, 1 year before the start of treatment, CD4+ T-cell numbers in the groups were not significantly different. However, at that time progressors already exhibited an extremely low anti-CD3-induced T-cell responsiveness compared with non-progressors. In all people T-cell responsiveness and the number of CD4+ T cells had improved 6 months after the start of zidovudine treatment. However, CD4+ T-cell numbers were not persistently elevated, and restoration of T-cell responsiveness was of only short duration. Our results show that zidovudine treatment in the asymptomatic phase of HIV infection did not result in a sustained improvement in T-cell function. Furthermore, they suggest that differences in clinical course among zidovudine-treated asymptomatics may be caused by heterogeneity of this group with respect to T-cell functional capacity at the start of treatment.

 

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