Leukocyte function and nonmalignant leukocyte disorders
作者:
Mary Dinauer,
期刊:
Current Opinion in Pediatrics
(OVID Available online 1993)
卷期:
Volume 5,
issue 1
页码: 80-87
ISSN:1040-8703
年代: 1993
出版商: OVID
关键词: ANI—autoimmune neutropenia of infancy;CGD—chronic granulomatous disease;C-CSF—granulocyte colony-stimulating factor;LAD—leukocyte adhesion deficiency;mRNA—messenger RNA;rlFN-y—recombinant human interferon gamma;SCN&mdas
数据来源: OVID
摘要:
This review summarizes recent literature regarding the clinical and molecular features of nonmalignant leukocyte disorders in children. Leukocyte adhesion deficiency and chronic granulomatous disease, two inherited disorders of neutrophil function, continue to be the best-characterized disorders with respect to specific molecular defects. The underlying causes of severe congenital neutropenia and cyclic neutropenia remain elusive. Clinical features of immune-mediated neutropenias and their differential diagnoses are also reviewed.
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