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Effects of Prenatal Gamma-Radiation on the Development of Mice and Its Modification by 2-Mercaptopropionylglycine

 

作者: P.K. Dev,   B.P. Pareek,   P.K. Goyal,   G. Mehta,   S.M. Gupta,  

 

期刊: Cells Tissues Organs  (Karger Available online 1983)
卷期: Volume 116, issue 4  

页码: 339-345

 

ISSN:1422-6405

 

年代: 1983

 

DOI:10.1159/000145758

 

出版商: S. Karger AG

 

关键词: Gamma-radiation;Embryonic resorption;Offspring mortality;Abnormalities;2-Mercaptopropionylglycine protection

 

数据来源: Karger

 

摘要:

Pregnant Swiss albino mice were whole-body exposed to 250, 150 and 50 R gamma-radiation from 60Co in the presence or absence of 2-mercaptopropionylglycine during selective organogenesis and fetal growth periods (days 11.25 and 14.25, 16.25 and 18.25 after conception, respectively). Both the protected and nonprotected pregnant females of 11.25-day gestation showed complete resorption of embryos irradiated with 250 R. With 150 R, in absence of the drug, 11.25-day gestating females showed partial resorption (76.10%). The percentage of parturition improved in the drug-treated females. Nonprotected females irradiated with 50 R showed slight resorption, while drug-treated females had normal parturition. Females irradiated during the fetal growth period showed no resorption. Also, no significant alteration in litter size and sex ratio of the newborn animals was noticed when irradiated during this period, both in the control and the experimental groups. Mortality of the young was higher in nonprotected animals as compared to the protected ones.

 

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