Growth Hormone and Exercise Tolerance in Patients with Cystic Fibrosis
作者:
Matthias Hütler,
Ralph Beneke,
期刊:
Sports Medicine
(ADIS Available online 2004)
卷期:
Volume 34,
issue 2
页码: 81-90
ISSN:0112-1642
年代: 2004
出版商: ADIS
关键词: Growth hormones, therapeutic use;Cystic fibrosis, treatment;Exercise tolerance
数据来源: ADIS
摘要:
Cystic fibrosis (CF) is a life-limiting inherited disorder characterised by pulmonary disease, pancreatic dysfunction and symptoms of malnutrition that are all interrelated with low exercise capacity and poor survival rate. Therapy with growth hormone (GH) may improve the reduced dimensional and functional capacity associated with poor nutritional status and catabolism and therefore improve exercise tolerance, quality of life and survival rate in patients with CF. The literature about GH treatment and its effect on exercise tolerance are rather limited, not always consistent and methodological concerns restrict further analysis. GH treatment may have beneficial effects on both growth and exercise tolerance without serious complications in prepubertal children with CF. The observed dimensional changes of the muscular, cardiovascular and pulmonary system seem to improve aerobic exercise capacity and respiratory and peripheral muscle strength. The physiological background of the observed changes is not yet fully understood, therefore, larger-scale studies with an optimised design are required.
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