ELIMINATION OF HYALURONIC ACID FROM THE BLOOD STREAM IN THE HUMAN
作者:
J. R. E. Fraser,
T. C. Laurent,
A. Engström‐Laurent,
U. G. B. Laurent,
期刊:
Clinical and Experimental Pharmacology and Physiology
(WILEY Available online 1984)
卷期:
Volume 11,
issue 1
页码: 17-25
ISSN:0305-1870
年代: 1984
DOI:10.1111/j.1440-1681.1984.tb00235.x
出版商: Blackwell Publishing Ltd
关键词: hyaluronic acid;human subjects;metabolism;plasma turnover;urinary excretion
数据来源: WILEY
摘要:
SUMMARY1. The removal of hyaluronic acid (HA) from the blood‐stream was studied in four normal human subjects after injection of high molecular weight preparations labelled with3H in the acetyl position. The plasma half‐life of the injected material ranged between 2.5 and 5.5 min.2. The daily turnover of HA in the circulation was estimated to be at least 150 mg. Its elimination was predominantly extrarenal, the upper molecular weight limit for renal excretion being 25 000.3. Evidence for rapid degradation was provided by the identification of3H2O in urine. Calculations from the specific activity of urinary3H2O indicated that approximately 55% of the acetyl content of the injected HA was completely oxidized within 3 h, and 85% within the first day.4. It is concluded that hyaluronic acid in the amounts currently used for therapeutic purposes should not accumulate significantly in the circulat
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