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Resolution, EPC‐Syntheses, Absolute Stereochemistry, and Pharmacology of the (S)‐(+)‐ and (R)‐(—)‐Isomers of the MAO‐A Inhibitor Tetrindole Hydrochloride

 

作者: Michael Bös,   Rolf Canesso,   Rolf Kettler,   Hans H. Keller,   Peter Schönholzer,  

 

期刊: Archiv der Pharmazie  （WILEY Available online 1995）
卷期: Volume 328, issue 7‐8  

页码: 619-622

 

ISSN:0365-6233

 

年代: 1995

 

DOI:10.1002/ardp.19953280710

 

出版商: WILEY‐VCH Verlag

 

关键词: pyrazinocarbazoles;imine reduction;titanocene catalyst;enantiomers;monoamine oxidases

 

数据来源: WILEY

 

摘要:

AbstractResolution of (RS)‐tetrindole (3) and enantioselective reductions of the imine7yielded (S)‐(+)‐(4) and (R)‐(−)‐tetrindole (5). The absolute stereochemistry of4was established by X‐ray analysis of the corresponding Mosher amide6. Fromin vitroas well asin vivodata (MAO‐inhibiton, levels of monoamines and their respective metabolites in rat brain),4was identified

 

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