Actin polymerization and depolymerization in relation to platelet shape change, aggregation and disaggregation
作者:
GlennJ. R.,
SpangenbergP.,
HeptinstallS.,
期刊:
Platelets
(Taylor Available online 1996)
卷期:
Volume 7,
issue 1-2
页码: 23-27
ISSN:0953-7104
年代: 1996
DOI:10.3109/09537109609079505
出版商: Taylor&Francis
数据来源: Taylor
摘要:
Actin is the most abundant platelet protein. It is present in two forms - a globular monomeric form (G-actin), and a filamentous polymeric form (F-actin). The F-actin is present both at the periphery of the cell in the form of a membrane skeleton which helps maintain cell shape, and also contributes to a three dimensional network that exists throughout the cell known as the cytoskeleton.1In the resting platelet, G-actin and F-actin exist in equilibrium, but on platelet activation this is disturbed in favour of the production of F-actin, with a corresponding decrease in the amount of G-actin. This process is known as actin polymerization.
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