Sitosterol FeedingChronic Animal and Clinical Toxicology and Tissue Analysis
作者:
R. Shipley,
R. Peeiffer,
M. Marsh,
R. Anderson,
期刊:
Circulation Research
(OVID Available online 1958)
卷期:
Volume 6,
issue 3
页码: 373-382
ISSN:0009-7330
年代: 1958
出版商: OVID
数据来源: OVID
摘要:
Sitosterol has previously been shown to block cholesterol absorption in both animals and man. Its clinical effectiveness in reducing hypercholesteremia has been repeatedly demonstrated. For periods exceeding 4 years, large amounts of sitosterol have been given daily for maintaining reduction of serum cholesterol concentration. The possibility of adverse side effects resulting from chronic administration has been considered. Long-term animal and clinical studies indicate that sitosterol has no detectable toxicity and does not accumulate or deposit in tissues.
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