THE EFFECT OF MACROMIXING ON OSCILLATORY BEHAVIOR IN RECOMBINANT FERMENTATION IN A CONTINUOUS STIRRED TANK REACTOR
作者:
P.R. PATNAIK,
期刊:
Chemical Engineering Communications
(Taylor Available online 1993)
卷期:
Volume 125,
issue 1
页码: 155-169
ISSN:0098-6445
年代: 1993
DOI:10.1080/00986449308936200
出版商: Taylor & Francis Group
关键词: Macromixing;Recombinant;Fermentation;CSTR
数据来源: Taylor
摘要:
A general model is presented for recombinant fermentation in a chemostat in which micromixing may be imperfect. Using the production of tryptophan synthetase as an example and the dilution rate,D, as the bifurcation parameter, conditions are first derived for Hopf bifurcation in a perfectly mixed chemostat. The bifurcation surfaces in three-dimensional space are such that oscillatory solutions exist above the surfaces and washout conditions below. A similar analysis is done for imperfect mixing. The bifurcation region is a concave hyperboloid in the [D,f, n]-space, wherefandn; are model parameters. It is argued that poor macromixing reduces the range ofDover which bifurcation to periodic solutions is possible.
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