Antiendothelial Cell Antibodies in Thromboangiitis Obliterans
作者:
JENS EICHHORN,
DAGMAR SIMA,
CARSTEN LINDSCHAU,
ANDREAS TUROWSKI,
HEINER SCHMIDT,
WOLFGANG SCHNEIDER,
HERMANN HALLER,
FRIEDRICH LUFT,
期刊:
The American Journal of the Medical Sciences
(OVID Available online 1998)
卷期:
Volume 315,
issue 1
页码: 17-23
ISSN:0002-9629
年代: 1998
出版商: OVID
关键词: Thromboangiitis obliterans;Vasculitis;Endothelial cell antibodies;Endothelial cells;Arteritis;Autoimmune disease
数据来源: OVID
摘要:
The occurrence of autoimmune phenomena in 28 patients with thromboangiitis obliterans (Buerger's disease) was determined. The following were sought: antineutrophil cytoplasmic antibodies against proteinase 3 (cANCA) and myeloperoxidase (pANCA), antinuclear antibodies, anti-Ro antibodies, anticardiolipin antibodies, and antiendothelial cell antibodies (AECA). For the last, an enzyme-linked immunosorbent assay was developed which verified the presence of the AECA phenomenon with immunofluorescence and confocal microscopy. Seven patients with active disease had AECA titers of 1,857± 450 arbitrary units (AU) compared with 126 ± 15 AU in 30 normal control subjects (P < 0.001) and 461 ± 41 AU in 21 patients in remission (P < 0.01). Antibodies from the sera of patients with active disease reacted not only with surface epitopes but also with sites within the cytoplasm of human endothelial cells. AECA may be useful in following disease activity and may play a role in the pathogenesis of thromboangiitis obliterans.
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