Normal Suppressive T Cell Function of Epstein-Barr Virus Induced B Cell Activation in Type 1 (Insulin Dependent) Diabetes Mellitus
作者:
KahanAlice,
PierreJean,
CharreireJeannine,
期刊:
Autoimmunity
(Taylor Available online 1990)
卷期:
Volume 5,
issue 4
页码: 257-264
ISSN:0891-6934
年代: 1990
DOI:10.3109/08916939009014710
出版商: Taylor&Francis
关键词: Suppressive T cell function;B lymphocyte activation;Epstein-Barr virus;type 1 (insulin dependent) diabetes mellitus
数据来源: Taylor
摘要:
Several studies have demonstrated abnormalities of T cell regulation of Epstein-Barr virus-induced B cell activation in systemic autoimmune diseases such as rheumatoid arthritis, systemic lupus erythemdtosus, and systemic sclerosis. However, a normal suppressive peripheral T cell function was observed in Graves' disease. To investigate whether this abnormality is a common feature to other autoimmune diseases, we studied T cell regulation of Epstein-Bar virus induced B cell activation in I5 newly diagnosed type 1 (insulin dependent) diabetes mellitus patients and 10 normal control subjects. Peripheral B lymphocytes infected with Epstein-Barr virus were cultured for 20 days in the presence or absence of autologous T cells at different ratios (1:1 and 1 : 4). IgM and IgG secretions into the supernatants were determined using an enzyme-linked immunosorbent assay. The extent of suppression when T cells were added, as measured by a suppression ratio, was not significantly different in type I (insulin dependent) diabetes mellitus patients and normal subjects.We conclude that in type 1 (insulin dependent) diabetes mellitus, the autoimmume reactivity is not dependent upon a generalized suppression defect. It can by hypothesized, therefore, that in type I diabetes mellitus as well as in Graves' disease, a local or organ specific suppressor deficit may induce the autoimmune phenomena.
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