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Rapid Determination of Acitretin or Isotretinoin and Their Major Metabolites by High-Performance Liquid Chromatography

 

作者: N.R. Al-mallah,   H. Bun,   A. Durand,  

 

期刊: Analytical Letters  （Taylor Available online 1988）
卷期: Volume 21, issue 9  

页码: 1603-1618

 

ISSN:0003-2719

 

年代: 1988

 

DOI:10.1080/00032718808066515

 

出版商: Taylor & Francis Group

 

关键词: Retinoids;Acitretin;Isotretinoin;Reversed-phase HPLC;Plasma determination

 

数据来源: Taylor

 

摘要:

A method is described for the quantitative analysis of acitretin and its isomer metabolite, or of isotretinoin and its principal metabolites, in human plasma. Following a simple extraction, the compounds are determined by reversed-phase high-performance liquid chromatography (HPLC) and detection at 350nm. This method was applied to plasma specimens collected from healthy volunteers and patients receiving single or multiple dose administrations of these compounds.

 

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