Neutralizing monoclonal antibodies to the AIDS virus
作者:
Elaine Thomas,
Jonathan Weber,
Jan McClure,
Paul Clapham,
Mitra Singhal,
M. Shriver,
Robin Weiss,
期刊:
AIDS
(OVID Available online 1988)
卷期:
Volume 2,
issue 1
页码: 25-30
ISSN:0269-9370
年代: 1988
出版商: OVID
关键词: HIV-1;neutralization;monoclonal antibodies;gp110;neutralizing epitope;type-specific
数据来源: OVID
摘要:
The production of neutralizing monoclonal antibodies (MAbs) will permit the exact localization of neutralizing epitopes on the AIDS virus, HIV-1. We describe the properties of seven MAbs to the envelope of the LAV-1 isolate. Five MAbs recognise the central portion of gp110, amino acids 279–472, and four of these are capable of high-titre neutralization of HIV-1, by infection inhibition, syncytial inhibition and vesicular stomatitis virus (VSV) pseudotype neutralization. One of the two MAbs to gp41 inhibits syncytium formation. Neutralization, live cell immunofluorescence and immunoprecipitation of gp110 are type-specific and restricted to HIV-1 isolates closely related to LAV-1
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