Induction of Heinz Body Formation by Sodium Dithionite
作者:
ImanishiHitoshi,
HosokawaKeimei,
ItanoHarvey A.,
期刊:
Hemoglobin
(Taylor Available online 1981)
卷期:
Volume 5,
issue 5
页码: 453-461
ISSN:0363-0269
年代: 1981
DOI:10.3109/03630268108991820
出版商: Taylor&Francis
数据来源: Taylor
摘要:
Incubation of normal erythrocytes with sodium dithionite resulted in the formation of Heinz bodies, but incubation with sodium metabisulfite did not. Addition of superoxide dismutase to the incubation medium increased the formation of Heinz bodies by sodium dithionite. Addition of catalase to suspensions of erythrocytes in the presence and absence of superoxide dismutase inhibited the formation of Heinz bodies. These findings indicate that hydrogen peroxide, not superoxide, is the active oxidant in Heinz body formation.
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