Nursing and other health care providers are challenged to create the future of health care. Health is synonymous with well-being framed holistically, mind, body, and spirit. Disparities are growing in health status for vulnerable population groups and the percentage of people who are uninsured is rising. New approaches to health care are needed in the current age of uncertainty. A comprehensive health promoting organization (HPO) model within an ecological systems framework is described. An operational example is delineated, Welcome Home Ministries HPO.