Effects of Metrifonate on Cognitive Decline in Alzheimer DiseaseA Double‐Blind, Placebo‐Controlled, 6‐Month Study
作者:
Robert Becker,
Jerry Colliver,
Stephen Markwell,
Pamela Moriearty,
Latha Unni,
Sandra Vicari,
期刊:
Alzheimer Disease and Associated Disorders
(OVID Available online 1998)
卷期:
Volume 12,
issue 1
页码: 54-57
ISSN:0893-0341
年代: 1998
出版商: OVID
关键词: Alzheimer disease;Acetylcholinesterase inhibitors;Cognitive decline;Memory;Metrifonate;Dichlorvos
数据来源: OVID
摘要:
Forty-seven patients with probable Alzheimer disease (AD) completed a 6-month double-blind study to compare metrifonate with placebo. The Alzheimer Disease Assessment Scale cognitive subscale score of the metrifonate group treated to a 50–70% inhibition of red blood cell acetylcholinesterase activity differed significantly from the placebo group score by 1.8 points (p< 0.03) due to a deterioration in cognitive performance in the placebo group (p< 0.01). Statistically significant deterioration also occurred in the Mini-Mental State Examination scores (p< 0.01) in the placebo-treated group. Adverse effects were uncommon and did not require adjustment of the dose of metrifonate or discontinuation of treatment. These findings extend our previous report of a favorable effect of metrifonate on cognitive symptoms in AD by showing clinical, not only statistical, significance.
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