Vigabatrin (Sabril)
作者:
Alan Kurland,
Thomas Browne,
期刊:
Clinical Neuropharmacology
(OVID Available online 1994)
卷期:
Volume 17,
issue 6
页码: 560-568
ISSN:0362-5664
年代: 1994
出版商: OVID
关键词: Partial epilepsy;γ-Aminobutyric acid;Pharmacotherapy
数据来源: OVID
摘要:
Vigabatrin is an irreversible inhibitor of the enzyme γ-aminobutyric acid (GABA) transaminase (GABA-T) and is marketed in >20 countries, including Canada but not the U.S.A., as an antiepileptic drug. Vigabatrin has demonstrated considerable efficacy against complex partial and secondarily generalized tonic-clonic seizures in patients refractory to conventional antiepileptic drugs. The most common side effects of vigabatrin are drowsiness, irritability, ataxia, dizziness, and headache. Behavioral disturbances are a rare and reversible side effect. The drug has no known systemic or irreversible side effects. The time course of action of vigabatrin depends principally upon regeneration of GABA-T inactivated by the drug.
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