Underexpression of the Apolipoprotein £4 Isoform in an Italian Population
作者:
Richard James,
Massimo Boemi,
Roberto Giansanti,
Paulo Fumelli,
Daniel Pometta,
期刊:
Arteriosclerosis and Thrombosis: A Journal of Vascular Biology
(OVID Available online 1993)
卷期:
Volume 13,
issue 10
页码: 1456-1459
ISSN:1049-8834
年代: 1993
出版商: OVID
关键词: apo E;lipoproteins;cholesterol;triglycerides;cardiovascular risk factors
数据来源: OVID
摘要:
Apolipoprotein (apo) E polymorphism was examined in a population of Italian blood donors. A significantly reduced frequency of the eX allele was observed in comparison to a combined Caucasian population. Apo E polymorphism was also associated with significant differences in plasma lipid and lipoprotein levels. Notably, total and low-density lipoprotein cholesterol as well as triglycerides were increased, whereas high-density lipoprotein cholesterol was decreased in carriers of the E4 isoform. This is the first report of a significantly lower frequency of the apo E4 isoform in a European population. The reduced occurrence of an apo E isoform, which is associated with a more atherogenic lipid/lipoprotein profile, may be a contributory factor to the relatively lower incidence of cardiovascular disease in the Italian population.
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