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Mechanisms of Intravenous Immunoglobulin Action in the Treatment of Autoimmune Disorders

 

作者: Claire Larroche,   Youri Chanseaud,   Paloma Garciadelapenalefebvre,   Luc Mouthon,  

 

期刊: BioDrugs  (ADIS Available online 2002)
卷期: Volume 16, issue 1  

页码: 47-55

 

ISSN:1173-8804

 

年代: 2002

 

出版商: ADIS

 

关键词: Autoimmune disorders, treatment;Immunoglobulins, therapeutic use

 

数据来源: ADIS

 

摘要:

Intravenous immunoglobulins (IVIg) are therapeutic preparations of normal human immunoglobulin (Ig) G obtained from pools of blood from more than 1000 healthy donors, and exert immunomodulatory effects in autoantibody-mediated and T-cell-mediated autoimmune disorders and systemic inflammatory diseases. IVIg mechanisms of action in autoimmune diseases have been extensively analysed during the last 15 years and include the following: (i) interaction of the IgG Fc fragment with Fc receptors on leucocytes and endothelial cells; (ii) interaction of infused IgG with complement proteins; (iii) monocyte and lymphocyte modulation of synthesis and release of cytokines and cytokine antagonists; (iv) modulation of cell proliferation and reparation; (v) neutralisation of circulating autoantibodies; (vi) selection of immune repertoires; and (vii) interaction with other cell-surface molecules on T and B lymphocytes.

 

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