Mechanisms of Intravenous Immunoglobulin Action in the Treatment of Autoimmune Disorders
作者:
Claire Larroche,
Youri Chanseaud,
Paloma Garciadelapenalefebvre,
Luc Mouthon,
期刊:
BioDrugs
(ADIS Available online 2002)
卷期:
Volume 16,
issue 1
页码: 47-55
ISSN:1173-8804
年代: 2002
出版商: ADIS
关键词: Autoimmune disorders, treatment;Immunoglobulins, therapeutic use
数据来源: ADIS
摘要:
Intravenous immunoglobulins (IVIg) are therapeutic preparations of normal human immunoglobulin (Ig) G obtained from pools of blood from more than 1000 healthy donors, and exert immunomodulatory effects in autoantibody-mediated and T-cell-mediated autoimmune disorders and systemic inflammatory diseases. IVIg mechanisms of action in autoimmune diseases have been extensively analysed during the last 15 years and include the following: (i) interaction of the IgG Fc fragment with Fc receptors on leucocytes and endothelial cells; (ii) interaction of infused IgG with complement proteins; (iii) monocyte and lymphocyte modulation of synthesis and release of cytokines and cytokine antagonists; (iv) modulation of cell proliferation and reparation; (v) neutralisation of circulating autoantibodies; (vi) selection of immune repertoires; and (vii) interaction with other cell-surface molecules on T and B lymphocytes.
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