Enzyme Induction by Enflurane in Man
作者:
M.,
Berman Orville,
Green R.,
Calverley N.,
Smith Edmond,
期刊:
Anesthesiology
(OVID Available online 1976)
卷期:
Volume 44,
issue 6
页码: 496-500
ISSN:0003-3022
年代: 1976
出版商: OVID
关键词: Anesthetics;volatile;enflurane; Biotransformation (drug);enflurane; Induction;enzymes
数据来源: OVID
摘要:
Concentrations of 6-β-hydroxycortisol (6-OHF), a polar metabolite of cortisol formed in the endoplasmic reticulum (microsomes) of the liver, and 17-hydroxyeorticosteroids (17-OHCS) were measured in the urines of six healthy adult male volunteers exposed to a mean of 9.6 MAC-hours of enflurane anesthesia as an index of possible enzyme induction. The ratio of 6-OHF to 17-OHCS in 24-hour urine specimens collected five days before anesthesia was compared with the ratio of these metabolites in 24-hour urine specimens collected 16 to 18 hours after anesthesia. The ratio of 6-OHF to 17-OHCS increased markedly in five and decreased slightly in one volunteer following anesthesia. The results indicate that enflurane may cause induction of hepatic microsomal enzymes.
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