In vivoandin vitroStudies on Endothelial Regeneration
作者:
P. Clopath,
K. Müller,
W. Stäubli,
R.R. Bürk,
期刊:
Pathophysiology of Haemostasis and Thrombosis
(Karger Available online 1979)
卷期:
Volume 8,
issue 3-5
页码: 149-157
ISSN:1424-8832
年代: 1979
DOI:10.1159/000214307
出版商: S. Karger AG
关键词: Endothelium;Ballooning;Evans-blue;Glucocorticoids;Hyperlipemia;Migration;3T3;Rabbit;Minipig;Atherosclerosis
数据来源: Karger
摘要:
Endothelial regeneration was studied in rabbit aorta after intra-arterial balloon catheterization. Most of the regenerated endothelium originated from existing branches which was assessed by the Evans-blue uptake pattern and confirmed by transmission and scanning electron microscopy. Glucocorticoid treatment enhanced re-endothelialization whereas hyperlipemic diet inhibited. Sera from minipigs fed an atherogenic diet consistently have less ability than sera from control pigs to stimulate in vitro the regeneration of wounded endothelium-like monolayers of 3T3-B cells. The deficiency is probably due to an inhibitor which appears and disappears with changes in the diet.
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