DIFFERENTIAL EFFECT OF GAMMA‐IRRADIATED AND HEAT‐TREATED LYMPHOCYTES ON T CELL ACTIVATION, AND INTERLEUKIN‐2 AND INTERLEUKIN‐3 RELEASE IN THE HUMAN MIXED LYMPHOCYTE REACTION
作者:
ROLF LOERTSCHER,
MARIO ABBUD-FILHO,
ALAN LEICHTMAN,
ARNAUD YTHIER,
JOHN WILLIAMS,
CHARLES CARPENTER,
TERRY STROM,
期刊:
Transplantation
(OVID Available online 1987)
卷期:
Volume 44,
issue 5
页码: 673-679
ISSN:0041-1337
年代: 1987
出版商: OVID
数据来源: OVID
摘要:
Heat-inactivated (45°C/1 hr) lymphocytes selectively activate suppressor T cells in the mixed lymphocyte reaction (MLR), while no significant proliferation and cytotoxic T lymphocyte activation can be detected. It is not well understood why hyperthermic treatment abolishes the stimulatory capacity of lymphocytes since HLA-DR molecules remain detectable immediately following heat exposure. In order to further characterize the requirements for Ts activation we studied the effects of hyperthermic treatment on cellular protein and DNA synthesis and cell surface protein expression in prolif-…
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