Effects of Estradiol-Induced Lesions of the Arcuate Nucleus on Gonadotropin Release in Response to Preoptic Stimulation in the Rat
作者:
J.R. Brawer,
K.B. Ruf,
F. Naftolin,
期刊:
Neuroendocrinology
(Karger Available online 1980)
卷期:
Volume 30,
issue 3
页码: 144-149
ISSN:0028-3835
年代: 1980
DOI:10.1159/000122990
出版商: S. Karger AG
关键词: Hypothalamus;Estradiol;Anovulation;Neuropathology;MPOA
数据来源: Karger
摘要:
Female Wistar rats treated with a single subcutaneous injection of 2 mg estradiol valerate (EV) develop gradually progressive, multifocal lesions of the arcuate nucleus. They also exhibit persistent vaginal estrus and endocrine profiles characteristic of animals sustaining anterior hypothalamic deafferentation. In this study, EV-treated females with the arcuate lesions released significantly less LH 1 h following electrochemical stimulation of the medial preoptic area (MPOA) than did normally cycling controls in proestrus. FSH release in response to MPOA stimulation was the same for both groups. As plasma LH concentrations were not significantly different between EV-treated and control animals 1 h after the injection of a potent LHRH analog, the reduced LH response to MPOA stimulation appears to reflect a primarily hypothalamic defect. However, the EV treatment also affected pituitary responsiveness to long-term stimulation as evidenced by reduced LH responses to the LHRH analog after 2 and 3 h. No such differences were seen in the FSH response.
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