Ticlopidine-Induced Lupus
作者:
Yolanda Braun-Moscovici,
Daniel Schapira,
Alexandra Balbir-Gurman,
Ronit Sevilia,
A. Nahir,
期刊:
JCR: Journal of Clinical Rheumatology
(OVID Available online 2001)
卷期:
Volume 7,
issue 2
页码: 102-105
ISSN:1076-1608
年代: 2001
出版商: OVID
关键词: Ticlopidine;Drug-induced lupus
数据来源: OVID
摘要:
Ticlopidine is a widely used drug for prevention of stroke and other serious vascular events with a multitude of possible side effects. An increasing number of drugs are being recognized as the triggering agents of drug-induced lupus. We describe three patients in whom the etiologic connection between ticlopidine and lupus was supported by the appearance of lupus-like features (fever, rash, arthritis, renal involvement, positive antinuclear and antihistone antibodies), shortly after drug initiation, and their gradual resolution after its discontinuation. If suggested by clinical or/and laboratory findings (fever of unknown cause, musculoskeletal involvement, hematologic abnormalities), the possibility of ticlopidine-induced lupus should be taken into consideration and appropriate investigations should be performed. Patients should resolve slowly but completely after withdrawal of ticlopidine.
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