Effect of Free Fatty Acids on Renal Metabolism of Very Low Density Lipoprotein Triglyceride
作者:
Mary Ellen Trimble,
期刊:
Kidney and Blood Pressure Research
(Karger Available online 1985)
卷期:
Volume 8,
issue 1
页码: 1-7
ISSN:1420-4096
年代: 1985
DOI:10.1159/000173028
出版商: S. Karger AG
关键词: Renal lipid metabolism;Very low density lipoproteins;Perfused kidney
数据来源: Karger
摘要:
Metabolism of very low density lipoprotein-triglyceride (VLDL-TG) was studied in the isolated perfused rat kidney (IPRK). Recirculating perfusate consisted of KrebsHenseleit bicarbonate buffer containing 6% defatted albumin and VLDL-TG which has been labelled in vitro with 14C-tripalmitin. Results show that the IPRK catabolizes VLDL-TG. Renal removal of VLDL-TG from perfusate was impaired in the presence of 1.0 mM palmitate. A lower palmitate concentration, 0.4 mM, was without effect. It is concluded that high concentrations of circulating free fatty acids impair renal metabolism of fatty acids derived from VLDL-TG.
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