Quinidine and Unidirectional Cation Fluxes in Atria
作者:
Richard Klein,
William Holland,
Betty Tinsley,
期刊:
Circulation Research
(OVID Available online 1960)
卷期:
Volume 8,
issue 1
页码: 246-252
ISSN:0009-7330
年代: 1960
出版商: OVID
数据来源: OVID
摘要:
The effect of quinidine on unidirectional fluxes of Na and K in isolated rabbit atria has been investigated and correlated with known effects of the drug on the electrical and mechanical properties of the heart. Quinidine caused a rapid inhibition of Na entry, which secondarily depressed K efflux. In addition, the drug depressed membrane permeability to K and caused a marked inhibition of active transport, both of which were relatively slow in onset.
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