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Induction of Cytotoxic Cell Activities by a Novel Cyclic Disulfide Compound, SA3443 in vivo

 

作者: SasanoMinoru,   TanakaMihoko,   NakataKatsuhiko,   MitaShiro,  

 

期刊: Immunopharmacology and Immunotoxicology  (Taylor Available online 1991)
卷期: Volume 13, issue 1-2  

页码: 121-133

 

ISSN:0892-3973

 

年代: 1991

 

DOI:10.3109/08923979109019695

 

出版商: Taylor&Francis

 

数据来源: Taylor

 

摘要:

Abstract(4R)-Hexahydro-7, 7–dimethyl-6–oxo-1, 2, 5–dithiazocine-4–carboxylic acid (SA3443) is a newly synthesized cyclic disulfide compound which offers potential hepatoprotective properties.The effect of SA3443 on the induction of natural killer (NK) and cytotoxic T lymphocyte (CTL) activities was investigated. NK activity in BALB/c mice splenic cells was investigated using YAC-1 cells as target cells. SA3443, at a dose range of 30–300 mg/kg/day, augmented NK activity significantly when administered orally once daily for 4 days before the assay. Alloantigen-specific CTL activity in splenic cells from BALB/c mice was detected 9 days after sensitization with C57BL/6 mice splenic cells. SA3443, at a dose of 100 mg/kg/day, augmented CTL activity significantly when administered orally, once daily for 4 days beginning after the sensitization and for 2 days before the assay, while a high dose of SA3443, at 300mg/kg, suppressed CTL activity.From these results, it is thought that SA3443 may assist in the elimination of hepatitis viruses from the liver in patients with chronic active hepatitis, by the activation of NK and/or CTL activities.

 

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