Physiologic Responses to Primary Blast
作者:
Richard J. Guy,
Emrys Kirkman,
Paul E. Watkins,
Graham J. Cooper,
期刊:
The Journal of Trauma: Injury, Infection, and Critical Care
(OVID Available online 1998)
卷期:
Volume 45,
issue 6
页码: 983-987
ISSN:0022-5282
年代: 1998
出版商: OVID
数据来源: OVID
摘要:
BackgroundPrimary blast injuries are produced by the blast shock wave. The critical determinant of survival is pulmonary injury, but acute cardiorespiratory responses to blast exposure are not well understood. The aim of this study was to investigate these changes.MethodsTwenty anesthetized rats were exposed to moderate blast overpressure, 10 animals receiving thoracic and 10 receiving abdominal exposure. Another 9 animals acted as controls. Respiration, heart rate, and blood pressure were recorded continuously before, during, and for 6 hours after blast exposure.ResultsAll animals exposed to thoracic blast demonstrated apnea, bradycardia, and hypotension after blast exposure, followed by a return to preblast values. No significant cardiovascular or respiratory changes were seen in animals in the other groups.ConclusionModerate thoracic blast injury produces a reflex triad of apnea, bradycardia, and hypotension that is not present after abdominal blast. These observations may have important implications for the immediate management of patients with blast injuries.
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