Flow Cytometry Analysis of T Cell Subsets in Skin of Patients with Specific Cutaneous Manifestation of B Non-Hodgkin Lymphoma
作者:
Giovanni Ricevuti,
Antonino Mazzone,
Davide Pasotti,
Renza Degiulio,
Severino Sacchi,
期刊:
Oncology
(Karger Available online 1991)
卷期:
Volume 48,
issue 3
页码: 180-183
ISSN:0030-2414
年代: 1991
DOI:10.1159/000226923
出版商: S. Karger AG
关键词: T lymphocyte;Skin immune system;Cutaneous lymphoma
数据来源: Karger
摘要:
Cutaneous lesions may be the atypical initial manifestation of blood disorders. Monoclonal antibodies identify surface phenotype of lymphocytes present in specific cutaneous lesions. We studied cutaneous infiltrates with flow cytometry in 10 cases of non-Hodgkin lymphoma. We characterized T cell subset in skin immune system. The percentage of T cells was compared to percentage observed in healthy specimens from same patient. T4 cells predominate in cutaneous infiltrates, with an increase in T4/T8 ratio. There was also an increase in T6+ cells, Langerhans cell markers in the skin. HLA-Dr + , T6 cells increased in all cases tested, indicative of dendritic cells. These data showed a modification of T lymphocytes only in skin infiltrate of lymphoma.
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