Cartilage Canal Growth: Experimental Approach in the Rat Tibia
作者:
E. Delgado-Baeza,
A. Nieto-Chaguaceda,
C. Miralles-Flores,
I. Santos-Alvarez,
期刊:
Cells Tissues Organs
(Karger Available online 1992)
卷期:
Volume 145,
issue 2
页码: 143-148
ISSN:1422-6405
年代: 1992
DOI:10.1159/000147356
出版商: S. Karger AG
关键词: Canal;Cartilage;Perichondrium;Chondroepiphysis;Thyroid hormone;Cell death
数据来源: Karger
摘要:
This paper studies the influence of an antimitotic factor (puromycin) and a hormonal factor (thyroid hormone, TH) on canal growth. The tibiae of 15 six-day-old rats were cultured in a serum-free chemically defined medium. The cultures were carried out for as long as 6 days. Our results show: (1) canal growth is not dependent on perichondrium or chondroepiphysis growth; (2) the canal is greater and has a complex pattern in a triiodothyronine (T3)-treated assay group; (3) round and multinucleated cells are more numerous in the T3-treated assay group than in the other groups. We hypothesize that the canal grows by a physiological phenomenon of programed cell death and that it is stimulated by TH.
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