Human pial vascular reactions to intravenous Nimodipine‐infusion during EC‐IC bypass surgery.
作者:
Auer L,
Oberbauer R,
Schalk H,
期刊:
Stroke
(OVID Available online 1983)
卷期:
Volume 14,
issue 2
页码: 210-213
ISSN:0039-2499
年代: 1983
出版商: OVID
数据来源: OVID
摘要:
In previous experimental work, the Ca-antagonist Nimodipine had shown a predominantly cerebroarterial dilatory effect. In the present double-blind study of 16 patients, pial arterial and venous reaction was investigated during EC-IC bypass surgery, infusing 1 microgram kg-1min-1 of Nimodipine intravenously. In pial arteries with resting diameters between 25 and 70 micrometers, a significant 18% dilatation was observed. Results are considered promising for future trials in the treatment and prevention of cerebral ischemia caused by vasoconstriction or vasospasm, especially vasospasm following subarachnoid hemorrhage.
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