Recent Advances in the Development of an Inhaled Insulin Product
作者:
André X.C.N. Valente,
Robert Langer,
Howard A. Stone,
David A. Edwards,
期刊:
BioDrugs
(ADIS Available online 2003)
卷期:
Volume 17,
issue 1
页码: 9-17
ISSN:1173-8804
年代: 2003
出版商: ADIS
关键词: Inhalation;Insulin, therapeutic use;Routes of administration
数据来源: ADIS
摘要:
Inhaled insulin first entered clinical human testing in the mid 1990s. Since then, the commercial potential and technical challenges of an inhaled insulin product have grown increasingly clear, with several pharmaceutical partnerships now targeting treatment of diabetes mellitus through inhalation products in clinical development. While clinical results to date show the therapy to be generally promising, recent data have raised questions related to human safety and slowed progress toward a commercial product. Answering these questions positively in the coming years will be critical to making inhalation therapy a practical diabetes-care reality.
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